[N-acetylcysteine in septic shock].
Identifieur interne : 000139 ( Main/Exploration ); précédent : 000138; suivant : 000140[N-acetylcysteine in septic shock].
Auteurs : Omar Ellouze [Tunisie] ; Nabil Frikha ; Sonia Ouerghi ; Taher Mestiri ; Mohamed Salah Ben AmmarSource :
- La Tunisie medicale [ 0041-4131 ] ; 2011.
Descripteurs français
- KwdFr :
- MESH :
- pharmacologie : Acétylcystéine, Piégeurs de radicaux libres.
- physiopathologie : Choc septique.
- traitement médicamenteux : Choc septique.
- usage thérapeutique : Acétylcystéine, Piégeurs de radicaux libres.
- Humains.
English descriptors
- KwdEn :
- MESH :
- chemical , pharmacology : Acetylcysteine, Free Radical Scavengers.
- chemical , therapeutic use : Acetylcysteine, Free Radical Scavengers.
- drug therapy : Shock, Septic.
- physiopathology : Shock, Septic.
- Humans.
Abstract
AIM
To focus on the various studies evaluating the effects of Nacetylcysteine in septic shock
METHODS
Main references obtained from the medical database Medline using the keywords: N-acetylcysteine; septic shock, free radicals.
RESULTS
Septic shock remains the leading cause of mortality in intensive care units. The progressive knowledge of the pathophysiology of septic shock, underline the production of free radicals and their cellular and microcirculatory effects. The Nacetylcysteine used mainly in paracetamol poisoning, has properties to control free radicals. The explosion of free radicals in septic shock has led to multiple studies assessing the role of N-acetylcysteine as an anti radical, and for its anti inflammatory action.
CONCLUSION
NAC seems to play an important role in septic shock to control free radicals and the inflammatory response. But these results remain contradictory. Some larger and more standardized studies should allow to evaluate the actual effects of NAC in septic shock.
PubMed: 22076894
Affiliations:
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Le document en format XML
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uniqKey="Salah Ben Ammar M" first="Mohamed" last="Salah Ben Ammar">Mohamed Salah Ben Ammar</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2011">2011</date><idno type="RBID">pubmed:22076894</idno><idno type="pmid">22076894</idno><idno type="wicri:Area/PubMed/Corpus">000682</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000682</idno><idno type="wicri:Area/PubMed/Curation">000678</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000678</idno><idno type="wicri:Area/PubMed/Checkpoint">000681</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000681</idno><idno type="wicri:Area/Main/Merge">000139</idno><idno type="wicri:Area/Main/Curation">000139</idno><idno type="wicri:Area/Main/Exploration">000139</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">[N-acetylcysteine in septic shock].</title><author><name sortKey="Ellouze, Omar" sort="Ellouze, Omar" uniqKey="Ellouze O" first="Omar" last="Ellouze">Omar Ellouze</name><affiliation wicri:level="1"><nlm:affiliation>Universite Tunis, El Manar, Tunisie.</nlm:affiliation><country xml:lang="fr">Tunisie</country><wicri:regionArea>Universite Tunis, El Manar</wicri:regionArea><wicri:noRegion>El Manar</wicri:noRegion></affiliation></author><author><name sortKey="Frikha, Nabil" sort="Frikha, Nabil" uniqKey="Frikha N" first="Nabil" last="Frikha">Nabil Frikha</name></author><author><name sortKey="Ouerghi, Sonia" sort="Ouerghi, Sonia" uniqKey="Ouerghi S" first="Sonia" last="Ouerghi">Sonia Ouerghi</name></author><author><name sortKey="Mestiri, Taher" sort="Mestiri, Taher" uniqKey="Mestiri T" first="Taher" last="Mestiri">Taher Mestiri</name></author><author><name sortKey="Salah Ben Ammar, Mohamed" sort="Salah Ben Ammar, Mohamed" uniqKey="Salah Ben Ammar M" first="Mohamed" last="Salah Ben Ammar">Mohamed Salah Ben Ammar</name></author></analytic><series><title level="j">La Tunisie medicale</title><idno type="ISSN">0041-4131</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acetylcysteine (pharmacology)</term><term>Acetylcysteine (therapeutic use)</term><term>Free Radical Scavengers (pharmacology)</term><term>Free Radical Scavengers (therapeutic use)</term><term>Humans (MeSH)</term><term>Shock, Septic (drug therapy)</term><term>Shock, Septic (physiopathology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acétylcystéine (pharmacologie)</term><term>Acétylcystéine (usage thérapeutique)</term><term>Choc septique (physiopathologie)</term><term>Choc septique (traitement médicamenteux)</term><term>Humains (MeSH)</term><term>Piégeurs de radicaux libres (pharmacologie)</term><term>Piégeurs de radicaux libres (usage thérapeutique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Acetylcysteine</term><term>Free Radical Scavengers</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Acetylcysteine</term><term>Free Radical Scavengers</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Shock, Septic</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Acétylcystéine</term><term>Piégeurs de radicaux libres</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Choc septique</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Shock, Septic</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Choc septique</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Acétylcystéine</term><term>Piégeurs de radicaux libres</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>AIM</b></p><p>To focus on the various studies evaluating the effects of Nacetylcysteine in septic shock</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>Main references obtained from the medical database Medline using the keywords: N-acetylcysteine; septic shock, free radicals.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Septic shock remains the leading cause of mortality in intensive care units. The progressive knowledge of the pathophysiology of septic shock, underline the production of free radicals and their cellular and microcirculatory effects. The Nacetylcysteine used mainly in paracetamol poisoning, has properties to control free radicals. The explosion of free radicals in septic shock has led to multiple studies assessing the role of N-acetylcysteine as an anti radical, and for its anti inflammatory action.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>NAC seems to play an important role in septic shock to control free radicals and the inflammatory response. But these results remain contradictory. Some larger and more standardized studies should allow to evaluate the actual effects of NAC in septic shock.</p></div></front></TEI><affiliations><list><country><li>Tunisie</li></country></list><tree><noCountry><name sortKey="Frikha, Nabil" sort="Frikha, Nabil" uniqKey="Frikha N" first="Nabil" last="Frikha">Nabil Frikha</name><name sortKey="Mestiri, Taher" sort="Mestiri, Taher" uniqKey="Mestiri T" first="Taher" last="Mestiri">Taher Mestiri</name><name sortKey="Ouerghi, Sonia" sort="Ouerghi, Sonia" uniqKey="Ouerghi S" first="Sonia" last="Ouerghi">Sonia Ouerghi</name><name sortKey="Salah Ben Ammar, Mohamed" sort="Salah Ben Ammar, Mohamed" uniqKey="Salah Ben Ammar M" first="Mohamed" last="Salah Ben Ammar">Mohamed Salah Ben Ammar</name></noCountry><country name="Tunisie"><noRegion><name sortKey="Ellouze, Omar" sort="Ellouze, Omar" uniqKey="Ellouze O" first="Omar" last="Ellouze">Omar Ellouze</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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